Regenerative Cell-Based Therapies: Cutting Edge, Bleeding Edge, and Off the Edge

Sufficient conditions for maximally edge-connected and super-edge-connected

Let $G$ be a connected graph with minimum degree $delta$ and edge-connectivity $lambda$. A graph ismaximally edge-connected if $lambda=delta$, and it is super-edge-connected if every minimum edge-cut istrivial; that is, if every minimum edge-cut consists of edges incident with a vertex of minimum degree.In this paper, we show that a connected graph or a connected triangle-free graph is maximall...

Cutting Edge: OFF Cycling of TNF

The Cutting Edge

“The bigger they are, the harder they fall” is a bit of wisdom that’s been around for a long time. But when it comes to pesticide application, the line should read, “The bigger they are, the closer they fall.” Large droplets are not as likely to drift off-target as smaller droplets. This basic principle lies behind many innovations to reduce drift when spraying herbicides. Nozzle manufacturers ...

The Cutting Edge

A 17-year-old white woman presented with a 2-year history of increasingly frequent episodes of erythromelalgia involving her hands, feet, and lower legs (Figure). She described the discomfort as “throbbing, burning, stinging.” Her symptoms occurred daily. The episodes involved her feet about 10 to 15 times during the day and involved her hands slightly less frequently. Whenever her feet got war...

The Cutting Edge: Challenges in Medical and Surgical Therapies

A 60-year-old circumcised man presented with an 8-month history of a gradually worsening painful lesion on his penis. He had previously been treated for several months with clobetasol and tacrolimus ointments. On physical examination, the shaft and coronal sulcus of the penis demonstrated significant erythema, erosions, crusting, and atrophic scarring (Figure 1). The findings on biopsy were con...